CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 213 enrolled
Drug / intervention
Cigarette +7 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02964182
NCT02964182N/ACompleted
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Evaluating Concomitant Use of Very Low Nicotine Content Cigarettes and E-Cigarettes Among Daily and Non-Daily Smokers

M.D. Anderson Cancer Center·interventional·Posted Nov 16, 2016·Updated Dec 9, 2025

In Brief

A clinical study evaluating Cigarette, Nicotine Replacement, and 5 other interventions for Cigarette Smoking-Related Carcinoma and Tobacco-Related Carcinoma. Completed, enrolled 213 participants across 1 site.

Detailed Summary

This trial studies what would happen if the nicotine levels in cigarettes are greatly reduced, but electronic cigarettes containing different amount of nicotine are available. Different levels of nicotine may effect certain behaviors, including withdrawal symptoms, nicotine cravings, and mood and may lead to changes in smoking behavior in current daily and intermittent smokers..

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedNov 16, 2016
Enrollment StartOct 26, 2017
Primary CompletionMar 4, 2025
TodayJul 2, 2026
Enrollment to primary: 7.4 yearsPosted 9.6 years ago

Interventions

Cigarettedrug

Smoke usual brand of cigarettes

Nicotine Replacementdrug

Received NRT (Electronic Cigarette - ECIG-Hi)

Nicotine Replacementdrug

Received NRT (Electronic Cigarette - ECIG-Hi)

Questionnaire Administrationother

Ancillary studies

Survey Administrationother

Ancillary studies

Very Low Nicotine Content Cigarettedrug

Smoke very low nicotine content cigarette

ECIG-Hidevice

Patients smoke ECIG-Hi for 3 weeks and then ECIG-Lo for 3 weeks.

ECIG-Lodevice

Patients smoke ECIG-Lo for 3 weeks and then ECIG-Hi for 3 weeks