At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Topical Phenylephrine 2.5% on Episcleral Venous Pressure in Normal Human Eyes
In Brief
A clinical study evaluating Phenylephrine 2.5% for Assess Phenylephrine on EVP and IOP. Completed, enrolled 20 participants across 1 site.
Detailed Summary
Phenylephrine hydrochloride ophthalmic solution is an alpha-1 adrenergic receptor agonist commonly used topically for dilation prior to ocular fundus examination. In the eye, phenylephrine acts locally as a potent vasoconstrictor and mydriatic by constricting ophthalmic blood vessels and the radial dilator muscle of the iris. Episcleral venous pressure (EVP) is a determinant of intraocular pressure (IOP) and can be measured non-invasively by venomanometry. Since phenylephrine is a vasoconstrictor, it may affect episcleral venous tone, but the effect on EVP is unknown. Understanding the physiology of episcleral veins helps us in better understanding of pathophysiology of glaucoma.
Study Details
Timeline
Interventions
Instilling phenylephrine 2.5% eye drop