At a glance
ClinicalIndex Comparison Record- ✓Healthy volunteers with no chronic physical illness
- ✓Age 18–25 years
- ✓Fluent in English
- ✕Chronic physical illness, especially inflammatory disorders (rheumatoid arthritis, asthma, allergies) or cardiac conditions
- ✕Presence or history of psychiatric illness (depression, anxiety)
- ✕Current prescription medication use
- ✕Pregnant or planning pregnancy
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Beta-Blockers and Inflammatory Responses to Acute Psychosocial Stress
In Brief
A Phase 4 clinical trial evaluating Propanolol hydrochloride and Placebo for Stress, Psychological and 3 related conditions. Completed, enrolled 92 participants across 1 site.
Detailed Summary
This randomized, double-blind, placebo-controlled study of propranolol will shed important light on how sympathetic nervous system (SNS) activation influences psychological and inflammatory responses to acute stress. Results from this study will inform both the basic science literature that is attempting to map the physiological mechanisms by which psychological stress may lead to poor mental and physical health, and may also ultimately have therapeutic relevance for individuals who are experiencing high levels of stress that is putting their health at risk. Utilizing a psychopharmacological approach allows for the circumvention of many of the challenges of conducting this research in human populations, and will allow for conclusions regarding causality, given that SNS activation will be experimentally manipulated, rather than relying on correlational measures of SNS activity that are difficult to assess and are not appropriate for asking if SNS activity causes changes in psychology and biology.
Study Details
Timeline
Interventions
One-time dose of 40mg of propranolol
Outside casing matching that of active drug