At a glance
ClinicalIndex Comparison Record- ✓Trauma patients with orthopedic injury admitted to hospital, hemodynamically stable, no longer in acute resuscitation phase (normal urine output >0.5 ml/kg/hr and SBP >90 mmHg for >6 hours without fluid bolus or transfusion)
- ✓Age 18–50 years
- ✓Hemoglobin <9 g/dL at enrollment or expected to drop below 9 g/dL with planned surgery
- ✕Pregnant (as confirmed by urine pregnancy test)
- ✕Prisoner
- ✕Severe head injury (Glasgow Coma Scale <8 for 48+ hours from presentation)
- ✕Known cardiac disease (coronary artery disease, atrial fibrillation, stent placement, congestive heart failure)
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion
In Brief
A Phase 4 clinical trial evaluating Blood and blood products for transfusion for Anemia. Completed, enrolled 161 participants.
Detailed Summary
The purpose of this study is to determine if there is a difference in outcomes between liberal transfusion (transfusing when hemoglobin drops below a set higher value number) and conservative transfusion (transfusing when hemoglobin drops below a set lower value number).
Study Details
Timeline
Interventions
Randomization would not occur until the patient's Hgb dropped below 7 g/dL. If the patient is randomized to the liberal arm, they would be transfused to keep their Hgb \>7 g/dL. If the patient is randomized to the conservative arm, they would not be transfused until their Hgb drops below 5.5 g/dL. If the patient's Hgb does not drop below 7.0 g/dL, randomization will not be done.