At a glance
ClinicalIndex Comparison Record- ✓Age 18-60 years, male or female outpatients
- ✓Confirmed Major Depressive Disorder diagnosis via SCID-IV-TR
- ✓Current depressive episode ≥1 month duration
- ✓HDRS-17 score ≥18 despite adequate trial of serotonin reuptake inhibitor
- ✕Lifetime history of Bipolar Disorder or any Psychotic Disorder
- ✕Substance abuse or dependence in past year (except nicotine/caffeine)
- ✕Significant neurological disorders: tics, brain lesions, seizure history (except therapeutic ECT), cerebrovascular accident, fainting, TIA within 2 years, aneurysm, dementia, Parkinson's, Huntington's, MS
- ✕Increased seizure risk including history of elevated intracranial pressure or significant head trauma with ≥5 minutes loss of consciousness
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Neuroimaging in Patients Undergoing TMS for Depression
In Brief
A clinical study evaluating transcranial magnetic stimulation for Treatment Resistant Depression. Completed, enrolled 33 participants across 1 site.
Detailed Summary
The goal of this project is to guide rTMS using functional magnetic resonance imaging (fMRI) in individuals with depression who did not respond to standard TMS treatment to evaluate whether targeted TMS using individualized functional MRI scans produce outcome superior to that of conventional approaches. The study team also plans to scan patients with Major Depression Disorder (MDD) patients prescribed to receive standard TMS for the first time before and after which they will have resting-state Functional Magnetic Resonance Imaging (rs-FMRI) scan in order to see if we can predict their responsiveness based on the functional connectivity maps.
Study Details
Timeline
Interventions
non invasive brain stimulation approach