At a glance
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Identification of Predictive Epigenetic Biomarkers of Lung Disease Severity in Cystic Fibrosis
In Brief
A clinical study evaluating spontaneous sputum for Cystic Fibrosis. Completed, enrolled 50 participants across 1 site.
Detailed Summary
The general aims of this project are (i) to identify predictive epigenetic biomarkers of lung disease severity in Cystic Fibrosis, (ii) to characterize a non-invasive cellular model, spontaneous sputum, for the analysis of these epigenetic biomarkers, (iii) to analyze the variations in DNA methylation for a same patient over time.
Study Details
Timeline
Interventions
CF patients carry a spontaneous sputum that is made in the context of bronchial drainage sessions conducted as part of usual care (inclusion, 6 months, 12 months, 18 months). The collection of spontaneous sputum is carried out within the bronchial drainage sessions, which are routinely performed at each visit. The spontaneous sputum is collected in a sterile container. In order not to contaminate the sputum with buccal epithelial cells will be asked patients to rinse the mouth before expectorate.