CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 39 enrolled
Drug / intervention
Piperacillin/Tazobactam +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02991937
NCT02991937Phase 4Completed
CompareCT.gov

Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children

NYU Langone Health·interventional·Posted Dec 14, 2016·Updated Jan 21, 2022

In Brief

A Phase 4 clinical trial evaluating Piperacillin/Tazobactam and Surgical Treatment for Appendicitis. Completed, enrolled 39 participants across 1 site.

Detailed Summary

Several prior studies have demonstrated that medical management of acute appendicitis in adults is a safe first-line therapy option. This study aims to determine whether non-operative management of uncomplicated acute appendicitis with antibiotics is non-inferior to operative management in a pediatric population. This study will be a randomized controlled trial comparing non-operative management with antibiotics to surgical management of uncomplicated acute appendicitis. The hypothesis is that antibiotics are not worse than surgery for the treatment of uncomplicated appendicitis in children.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAppendicitis
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
2017201820192020202120222023202420252026
First PostedDec 14, 2016
Enrollment StartDec 1, 2016
Primary CompletionDec 1, 2020
TodayJul 2, 2026
Enrollment to primary: 4 yearsPosted 9.5 years ago

Interventions

Piperacillin/Tazobactamdrug

24 hours of IV antibiotic administration

Surgical Treatmentprocedure

Appendectomy