At a glance
ClinicalIndex Comparison Record- ✓Age 18–85 years
- ✓ASA Physical Status 1–3
- ✓Scheduled for elective open or laparoscopic abdominal surgery (colorectal, hysterectomy)
- ✓Anticipated hospitalization of at least 3 nights
- ✕Hepatic disease (liver enzymes >2× normal)
- ✕Renal disease (serum creatinine >2× normal)
- ✕Bupivacaine sensitivity or known allergy
- ✕Pregnant or breastfeeding women
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Comparison of Bilateral Transversus Abdominis Plane Block With Exparel Verus Continuous Epidural Analgesia With Bupivacaine: A Randomized, Controlled Trial
In Brief
A clinical study evaluating TAP block, Epidural analgesia, and 2 other interventions for Pain, Postoperative and Major Abdominal Surgery. Completed, enrolled 514 participants across 2 sites.
Detailed Summary
Comparison of Bilateral Transversus Abdominis Plane Block with Exparel versus Continuous Epidural Analgesia With Bupivacaine
Study Details
Timeline
Interventions
Transversus Abdominis Plane (TAP) blocks will be performed preoperatively. An in-plane ultrasound will be used in TAP block procedure.
Epidural catheters will be inserted preoperatively.
Once the target area is positioned, plain bupivacaine 0.25%, 20ml will be given to open the space and then single dose (10ml) of liposomal bupivacaine (Exparel) mixed with saline (10 ml) will be injected in each side. Total dose of Exparel will be 20 mL.
Once an epidural catheter is successfully positioned, an infusion will be initiated intraoperatively. Bupivacaine standard solution without additives will be prepared for each patient in epidural group.