CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 73 enrolled
Drug / intervention
oral dexamethasone +1 moredrug
Likely dose
oral dexamethasone 10mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03005522
NCT03005522N/ACompleted

The Effects of Dexamethasone on the Time to Pain Resolution in Dental Periapical Abscess

University of Arizona·interventional·Posted Dec 29, 2016·Updated Dec 28, 2022

In Brief

A clinical study evaluating oral dexamethasone and Placebo Oral Capsule for Dental Research and Pharmaceutical Preparations, Dental. Completed, enrolled 73 participants across 1 site.

Detailed Summary

An individual's quality of life can be seriously affected by the severity of dental pain. The emergency department is a common place to find those seeking relief from their dental pain- often times seeking removal of the affected tooth, dental anesthetic injections or oral pain medications. There are a number of dental infections that cause this type of debilitating pain. One such dental infection is termed periapical abscess. This infection involves the tooth pulp. These infections can arise in three ways: introduction through a defect in the enamel and dentin; from a periodontal pocket or an adjacent tooth; or hematogenous seeding of the pulp from mechanical irritation. As this disease process continues there are a number of complications including chronic pain and, more seriously, the spread of infection into deep spaces which can be a life threatening condition. The Emergency Department treatment of this infection includes pain control, antibiotics and dental referral for ultimate management of the infection. The purpose of our study is to investigate whether the addition of oral steroids will alter the time until patient experiences improvement in their dental pain. Steroids are a commonly used anti-inflammatory that is used in the Emergency Departmentfor the purpose of pain relief from throat pain. As the pain from periapical infection is thought to be largely from the pressure we speculate that the anti-inflammatory effects of steroids may decrease the inflammation thus the pressure and may ultimately lead to a decrease in time until the patient experiences some relief from their pain.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedDec 29, 2016
Enrollment StartJan 1, 2017
Primary CompletionDec 1, 2019
TodayJul 2, 2026
Enrollment to primary: 2.9 yearsPosted 9.5 years ago

Interventions

oral dexamethasonedrug

Patient will be dosed with either placebo or with the study drug, 10mg oral dexamethasone, to be administered by mouth one time in the ED

Placebo Oral Capsuledrug

dosed with placebo