CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 60 enrolled
Drug / intervention
Bupivacaine 0.25% +4 moredrug
Likely dose
Clonidine 1.66mcg/ccfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03007966
NCT03007966Phase 2Completed

Ilioinguinal/Iliohypogastric vs. Quadratus Lumborum Nerve Blockade for Elective Open Inguinal Herniorrhaphy

Wake Forest University Health Sciences·interventional·Posted Jan 2, 2017·Updated Nov 18, 2019

In Brief

A Phase 2 clinical trial evaluating Ilioinguinal / Iliohypogastric Block, Quadratus Lumborum Block, and 3 other interventions for Nerve Block and 2 related conditions. Completed, enrolled 60 participants across 1 site.

Detailed Summary

Open inguinal herniorrhaphy is a common outpatient surgical procedure. Post-operative pain can be a significant hindrance to discharge from the post anesthesia care unit. Pain can be treated with opioid therapy, but the literature supports that these agents are known to create or exacerbate adverse effects and complications, including post-operative nausea and vomiting, hypoxia, and urinary retention. In contrast, analgesia provided by regional anesthesia results in a decreased risk of the aforementioned complications.1 Because of this, various regional anesthetic techniques have been developed to provide analgesia following open herniorrhaphy. One technique is a combined ilioinguinal and iliohypogastric nerve block (IINB), which has been shown to decrease the initial pain after inguinal herniorrhaphy.2 The quadratus lumborum block (QLB) is a newer regional anesthetic technique that we think could be as effective as IINB at providing pain control following open herniorrhaphy. Additionally, because local anesthetic injected during a QLB has the potential to spread cranially into the thoracic paravertebral space following its lumbar deposition it could lead to alleviation of both somatic and visceral pain.3 This might therefore improve the quality and or duration of analgesia as compared to the IINB. To the best of the author's knowledge there has been no investigation comparing the efficacy, with regards to post-operative pain management, between IINB and QLB.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2017201820192020202120222023202420252026
First PostedJan 2, 2017
Enrollment StartJan 30, 2017
Primary CompletionFeb 17, 2018
TodayJul 2, 2026
Enrollment to primary: 1.0 yearsPosted 9.5 years ago

Interventions

Ilioinguinal / Iliohypogastric Blockprocedure

Patients randomized to this arm will receive 25cc's of Bupivacaine 0.25% + Epinephrine 1:200k + Clonidine 1.66mcg/cc administered via an ultrasound guided ilioinguinal / iliohypogastric block technique.

Quadratus Lumborum Blockprocedure

Patients randomized to this arm will receive 25cc's of Bupivacaine 0.25% + Epinephrine 1:200k + Clonidine 1.66mcg/cc administered via an ultrasound guided quadratus lumborum block technique.

Bupivacaine 0.25%drug

Administered as part of the local anesthetic mixture

Epinephrine 1:200kdrug

Administered as part of the local anesthetic mixture

Clonidine 1.66mcg/ccdrug

Administered as part of the local anesthetic mixture