At a glance
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Effects of Mild Hypoglycaemia on Cognitive Function in Type 2 Diabetes
In Brief
A clinical study evaluating Hypoglycaemic clamp and Euglycaemic clamp for Diabetes Mellitus, Type II and 2 related conditions. Completed, enrolled 28 participants across 1 site.
Detailed Summary
Hypoglycaemia in subjects suffering from type 2 diabetes may have substantial consequences including a significant negative impact on quality of life. Further, repeated minor hypoglycaemias may result in significant productivity losses. Here, the investigators propose to provide quantitative results on cognition during an acute mild hypoglycaemic episode (target plasma glucose 3 mmol/L) in 28 subjects with type 2 diabetes. Data will be provided on executive function, attention and memory.
Study Details
Timeline
Interventions
The clamp is performed by insulin and adjustable 20% glucose infusions, with the aim to lower and keep plasma blood glucose levels at 3 mmol/L for outcome measurements.
The clamp is performed by insulin and adjustable 20% glucose infusions, with the aim to keep plasma blood glucose levels at 6 mmol/L for outcome measurements.