At a glance
ClinicalIndex Comparison Record- ✓Septic shock requiring vasopressor to maintain MAP ≥65 mmHg with serum lactate >2 mmol/L in the absence of hypovolemia
- ✕Congestive pulmonary edema or left ventricular ejection fraction ≤40%
- ✕Known right heart pathologies
- ✕Marked ascites, significant bowel dilatation, or conditions causing abdominal hypertension
- ✕Body mass index ≥30 kg/m²
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Randomized Controlled Trial of Inferior Vena Cava Ultrasound-guided Fluid Management in Septic Shock Resuscitation
In Brief
A clinical study evaluating IVC Ultrasound-guided, Antibiotics, and 1 other intervention for Septic Shock. Completed, enrolled 211 participants across 1 site.
Detailed Summary
The primary aim of this study is to evaluate the 30-day mortality outcome of the septic shock patients who are treated with ultrasound-assisted fluid management using change of the inferior vene cava (IVC) diameter during respiratory phases in the first 6 hours compared with those treated with "usual-care" strategy.
Study Details
Timeline
Interventions
IVC is identified in longitudinal section in the subcostal area of a patient using the curvilinear probe of standard ultrasound. The selected area of IVC diameter measurement is set at 2 centimeters distal to the confluence of hepatic vein by M-mode coupled by two-dimensional mode on frozen screen images using the Sonosite® X-porte.
Prompt empirical antibiotics will be given to the patients within one hour before the treatment allocation.
The threshold to the need of a vasopressor is set at mean arterial pressure below 65 mmHg if a patient's condition does not response to the fluid therapy.