At a glance
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Short Term Effects of Carbidopa-levodopa in Neovascular AMD
In Brief
A Phase 2 clinical trial evaluating carbidopa-levodopa 25-100 mg tablets for Age-related Macular Degeneration. Completed, enrolled 20 participants across 1 site.
Detailed Summary
From 3 large patient databases, patients diagnosed with AMD who have never taken levodopa(L-DOPA) containing medications have a mean age of diagnosis at 71 years. Patients who have been treated with L-DOPA containing medications have a mean age of diagnosis of AMD at 79 years. L-DOPA binds to GPR143 in the retinal pigment epithelium, and releases PEDF, which protects the retina and downregulates VEGF, which is the cause of neovascularization. The Investigators will evaluate the safety and tolerability of carbidopa-levodopa in patients with Neovascular AMD, and measure the effects on visual acuity and retinal abnormalities due to "wet" (neovascular) AMD.
Study Details
Timeline
Interventions
See arm/group descriptions