CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 54 enrolled
Drug / intervention
Cyclophosphamide +8 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03023046
NCT03023046Phase 2Completed
CompareCT.gov

A Phase II Study of Dose-Adjusted Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin (DA-EPOCH) as Front-Line Therapy for Adults With Acute Lymphoblastic Leukemia/Lymphoma

University of Washington·interventional·Posted Jan 18, 2017·Updated Jul 13, 2022

In Brief

A Phase 2 clinical trial evaluating Cyclophosphamide, Dasatinib, and 7 other interventions for Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma. Completed, enrolled 54 participants across 1 site.

Detailed Summary

This phase II trial studies how well etoposide, prednisone, vincristine sulfate, cyclophosphamide, and doxorubicin (DA-EPOCH) works in treating patients with acute lymphoblastic leukemia or lymphoblastic lymphoma. Drugs used in chemotherapy, such as etoposide, prednisone, vincristine sulfate, cyclophosphamide, and doxorubicin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAcute Lymphoblastic Leukemia, Lymphoblastic Lymphoma
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI)

Timeline

Phase 2CompletedFinished
2017201820192020202120222023202420252026
First PostedJan 18, 2017
Enrollment StartFeb 23, 2017
Primary CompletionMay 20, 2021
Study CompletionMay 1, 2022
TodayJul 2, 2026
Enrollment to primary: 4.2 yearsPosted 9.5 years ago

Interventions

Cyclophosphamidedrug

Given IV

Dasatinibdrug

Given PO

Doxorubicindrug

Given IV

Etoposidedrug

Given IV

Imatinib Mesylatedrug

Given PO

Laboratory Biomarker Analysisother

Correlative studies

Prednisonedrug

Given PO

Rituximabbiological

Given IV

Vincristine Sulfatedrug

Given IV