At a glance
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Technology Development for Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain
In Brief
A clinical study evaluating Open-Loop DBS, Sham Stimulation, and 1 other intervention for Chronic Pain and 3 related conditions. Active but no longer recruiting, targeting 4 participants across 1 site.
Detailed Summary
Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but current technology is unable to reliably achieve long-term pain symptom relief. A "one-size-fits-all" approach of continuous, 24/7 brain stimulation has helped patients with some movement disorders, but the key to reducing pain may be the activation of stimulation only when needed, as this may help keep the brain from adapting to stimulation effects. By expanding the technological capabilities of an investigative brain stimulation device, the investigators will enable the delivery of stimulation only when pain signals in the brain are high, and then test whether this more personalized stimulation leads to reliable symptom relief for chronic pain patients over extended periods of time.
Study Details
Timeline
Interventions
Conventional brain stimulation that is tonically providing stimulation, without feedback
No Active Stimulation
Feedback enabled brain stimulation, where stimulation is provided on demand in response to pain biomarkers.