CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 102 enrolled
Drug / intervention
Oral Glucose Tolerance Test (OGTT) +5 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03032640
NCT03032640N/ACompleted
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Interactions of Human Gut Microbiota With Intestinal Sweet Taste Receptors

AdventHealth Translational Research Institute·interventional·Posted Jan 26, 2017·Updated Feb 2, 2023

In Brief

A clinical study evaluating Oral Glucose Tolerance Test (OGTT), Assessment of dietary compliance, and 4 other interventions for Obesity. Completed, enrolled 102 participants across 1 site.

Detailed Summary

The purpose of this study is to collect data to examine whether short-term consumption of non-caloric artificial sweeteners (NCASs), such as saccharin, can lead to changes in blood sugar levels and in the composition of the bacteria in the large intestine.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsObesity
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedJan 26, 2017
Enrollment StartJan 26, 2017
Primary CompletionMar 21, 2018
Study CompletionOct 18, 2022
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 9.4 years ago

Interventions

Oral Glucose Tolerance Test (OGTT)other

Once we test the fasting plasma glucose (after an overnight fast), subject will receive a 75g glucose beverage they will have to drink within 5 minutes. Then after drinking the beverage, 8 blood samples will be collected through the IV catheter, over the next 3 hours.

Assessment of dietary complianceother

Assessment of consumption of non-caloric artificial sweeteners

Stool samplingother

Subjects will provide a stool sample.

Sodium Saccharinother

Subjects in group 1 and group 3 will be provided with sodium saccharin.

Placeboother

Subjects in group 2 will be provided with placebo.

Lactisoleother

Subjects in group 3 and group 4 will be provided with lactisole.