CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 12 enrolled
Drug / intervention
Intra-detrusor injection of Onabotulinumtoxin-Adrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03033355
NCT03033355N/ACompleted
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A Prospective Study of Higher Neural Control Changes Following Intra-detrusor Injection of Onabotulinumtoxin-A in Patients With Multiple Sclerosis and Lower Urinary Tract Symptoms.

The Methodist Hospital Research Institute·observational·Posted Jan 26, 2017·Updated Aug 5, 2025

In Brief

An observational study evaluating Intra-detrusor injection of Onabotulinumtoxin-A for Multiple Sclerosis and 4 related conditions. Completed, enrolled 12 participants across 1 site.

Detailed Summary

The purpose of this research study is to evaluate higher neural changes following intra-detrusor injection of Onabotulinumtoxin-A (BTX-A) in patients with Multiple Sclerosis (MS). We will use our prospectively collected cohort of patients. Concurrent Urodynamic and Functional Magnetic Resonance (fMRI) data will be recorded pre- and post-intravesical injection of BTX-A in patients with Multiple Sclerosis (MS) and neurogenic detrusor activity (NDO).

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsMultiple Sclerosis, Lower Urinary Tract Symptoms, Neurogenic Bladder, Detrusor, Overactive, Urge Incontinence
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedJan 26, 2017
Enrollment StartFeb 1, 2014
Primary CompletionMar 1, 2019
TodayJul 2, 2026
Enrollment to primary: 5.1 yearsPosted 9.4 years ago

Interventions

Intra-detrusor injection of Onabotulinumtoxin-Adrug

Using cystoscopy, Onabotulinumtoxin-A is injected into the bladder.