At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
MTNR1B SNP*Food Timing Interaction on Glucose Control in a Late Eater Mediterranean Population
In Brief
A clinical study evaluating Early OGTT and Late OGTT for Non-Diabetic Disorder of Endocrine Pancreas. Completed, enrolled 889 participants across 1 site.
Detailed Summary
The purpose of this investigation is to assess the role of melatonin receptor 1B (MTNR1B) single nucleotide polymorphism (SNP)\*food timing interaction on glucose control in the deleterious effect in a vulnerable population with regular exposure to concurrent high melatonin and food intake as late night eaters (those having dinner within 2.5 h before their usual bed time). With the results from this study, we expect to advance our understanding of the role of endogenous melatonin on glucose metabolism in late night eaters and carriers of the MTNR1B risk allele, with potential implications on the guidelines to mitigate risk of type 2 diabetes in late night eaters and carriers of the MTNR1B risk allele.
Study Details
Timeline
Interventions
Oral glucose tolerance test using identical mixed 75 gr of glucose under early condition (4 hours before habitual bedtime)
Oral glucose tolerance test using identical mixed 75 gr of glucose under late condition (1 hour before habitual bedtime)