CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 80 enrolled
Drug / intervention
PATH-MCI +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03043573
NCT03043573N/ACompleted

Problem Adaptation Therapy for Mild Cognitive Impairment and Depression

Weill Medical College of Cornell University·interventional·Posted Feb 6, 2017·Updated Aug 12, 2025

In Brief

A clinical study evaluating PATH-MCI and Supportive Therapy for Cognitive Impairment and Depression. Completed, enrolled 80 participants across 4 sites.

Detailed Summary

The present collaborative R01 study, between Cornell and Johns Hopkins, aims to compare Problem Adaptation Therapy for Mild Cognitively Impaired Older Adults (PATH-MCI) vs. Supportive Therapy for Cognitively Impaired Older Adults (ST-CI) in improving cognitive, affective, and functioning outcomes.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedFeb 6, 2017
Enrollment StartJul 1, 2017
Primary CompletionSep 19, 2024
TodayJul 2, 2026
Enrollment to primary: 7.2 yearsPosted 9.4 years ago

Interventions

PATH-MCIbehavioral

Problem Adaptation Therapy for Mild Cognitively Impaired Adults (PATH-MCI) differs from standard of care psychotherapy by offering a combination of emotion regulation techniques with the provision of environmental adaptation tools (notes, checklists, calendars, etc.), the use of the WellPATH app, and the participation of a willing and available caregiver.

Supportive Therapybehavioral

ST focuses on: 1. facilitating expression of affect; 2. conveying to the patient that he or she is understood; 3. offering empathy; and 4. highlighting positive experiences. The ST manual aims to standardize nonspecific therapeutic factors.