At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Impact of Intraoperative Fluid Management on Electrolyte and Acid-base Variables
In Brief
A Phase 3 clinical trial evaluating Normal Saline, Lactated Ringer, and 1 other intervention for Anesthesia. Completed, enrolled 59 participants across 1 site.
Detailed Summary
During major surgical procedures, intravascular volume is maintained with the administration of isotonic fluids such as Lactated Ringers (LR), Normal Saline (NS) or Normosol-R. All three of these fluids are in common clinical use for this purpose. As large volumes of NS may result in a dilutional acidosis and an increasing base deficit, it may cloud clinical decision making when resuscitative efforts are guided by acid-base status on routine arterial blood gas analysis. This is a prospective, randomized study to evaluate changes in acid-base and electrolyte (sodium, potassium, calcium) status with the use of various isotonic fluids for intraoperative resuscitation.
Study Details
Timeline
Interventions
IV infusion of 0.9% NaCl throughout surgery.
IV infusion of lactated ringer throughout surgery.
IV infusion of Normosol throughout surgery.