At a glance
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A Randomized Trial to Compare Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day
In Brief
A Phase 3 clinical trial evaluating Very low nicotine content (VLNC) cigarettes and nicotine replacement therapy (NRT) and Reduce cigarettes per day (CPD) with nicotine replacement therapy (NRT) for Tobacco Use Disorder. Completed, enrolled 74 participants across 1 site.
Detailed Summary
The FDA recently gained the authority to regulate the nicotine content of cigarettes. Prior research suggests that smokers who switch to very low nicotine content (VLNC) cigarettes experience reduced addiction to nicotine and are more likely to quit smoking. Currently, the most common method for smokers to reduce their nicotine intake is to reduce their number of cigarettes per day (CPD). No research has compared reducing smokers' nicotine intake by switching to VLNC cigarettes vs by reducing CPD with regard to decreasing dependence or quitting; thus the investigators will examine the two strategies by randomizing smokers to 1) switch to VLNC cigarettes or 2) reduce CPD. In addition, all smokers will use the nicotine patch to help them reduce their nicotine intake.
Study Details
Timeline
Interventions
Participants will switch to very low nicotine content (VLNC) cigarettes with the aid of nicotine replacement therapy (NRT)
Participants will reduce cigarettes per day (CPD) with the aid of nicotine replacement therapy (NRT)