CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 80 enrolled
Drug / intervention
Metoprolol Succinate ER +3 moredrug
Likely dose
Metoprolol Succinate ER 50mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03070184
NCT03070184Phase 2Completed
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Racial Differences in the Natriuretic Peptide Response to Exercise and Beta-blockers

University of Alabama at Birmingham·interventional·Posted Mar 3, 2017·Updated Mar 12, 2025

In Brief

A Phase 2 clinical trial evaluating Exercise capacity VO2 max determination, Standardized meals, and 2 other interventions for Healthy and Pre Hypertension. Completed, enrolled 80 participants across 1 site.

Detailed Summary

The purpose of the study is to understand the origins of differential response to beta-blockers in African-Americans and may provide insight regarding racial differences in cardiovascular risk.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHealthy, Pre Hypertension
CountriesUnited States
CollaboratorsNational Heart, Lung, and Blood Institute (NHLBI)

Timeline

Phase 2CompletedFinished
2017201820192020202120222023202420252026
First PostedMar 3, 2017
Enrollment StartApr 30, 2017
Primary CompletionDec 31, 2023
Study CompletionApr 30, 2024
TodayJul 2, 2026
Enrollment to primary: 6.7 yearsPosted 9.3 years ago

Interventions

Exercise capacity VO2 max determinationother

Each participant's maximal oxygen capacity will be determined using a modified Bruce treadmill protocol.

Standardized mealsdietary

Participants will consume the standardized study diet for 3 days provided by the clinical research unit's metabolic kitchen (at UAB).

Exercise challengeother

Each participant will walk at 70 % of his/her VO2max for 20 minutes on treadmill.

Metoprolol Succinate ERdrug

Each participant will receive metoprolol succinate starting at 50mg/day, titrated bi-weekly up to 200 mg/day for total duration of 6 weeks.