CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 210 enrolled
Drug / intervention
EVALUATION OF VSX1, SOD1, and TIMP3 genesother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03071302
NCT03071302N/ACompleted
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Evaluation of Tomographic and Genetic Aspects of Keratoconus Patients Compared to Sounds Corneas

Sao Jose do Rio Preto Medical School·interventional·Posted Mar 6, 2017·Updated Mar 6, 2017

In Brief

A clinical study evaluating EVALUATION OF VSX1, SOD1, and TIMP3 genes for Keratoconus and Keratoconus, Unspecified, Bilateral. Completed, enrolled 210 participants across 1 site.

Detailed Summary

Evaluation of tomographic (Pentacam) parameters and genetic parameters of Visual System Homeobox 1 (VSX1), Superoxide Dismutase (SOD1), Tissue Inhibitors of Metalloproteinases (TIMP3) genes of keratoconus patients diagnosed by clinical exam and topographic pattern. Basically we are screening patients that don't have keratoconus that those have keratoconus. The pentacam index of corneal curvature, thinnest point, corneal high order aberrations, posterior and anterior elevation, corneal densitometry, corneal volume were investigated. To analyze the genes, we took corneal epithelium samples of patients submitted to cross linking compared to (PRK) Photo Refractive Keratectomy ones. Also will be evaluated the genes of peripheral blood.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsKeratoconus, Keratoconus, Unspecified, Bilateral
CountriesBrazil
CollaboratorsFundação de Amparo à Pesquisa do Estado de São Paulo

Timeline

N/ACompletedFinished
20162017201820192020202120222023202420252026
First PostedMar 6, 2017
Enrollment StartAug 1, 2015
Primary CompletionDec 31, 2016
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 9.3 years ago

Interventions

EVALUATION OF VSX1, SOD1, and TIMP3 genesother

Evaluation of VISX1, SOD1, TIMP3 genes in corneal epithelium, and in peripheral blood. Evaluation of pentacam parameters