CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 316 enrolled
Drug / intervention
Ipilimumab plus nivolumab +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03075423
NCT03075423Phase 2Completed

A Phase 2, Randomized, Open-Label Study of Nivolumab Combined With Ipilimumab Versus Standard of Care in Subjects With Previously Untreated and Advanced (Unresectable or Metastatic) Non-clear Cell Renal Cell Carcinoma (nccRCC)

Goethe University·interventional·Posted Mar 9, 2017·Updated Sep 26, 2025

In Brief

A Phase 2 clinical trial evaluating Ipilimumab plus nivolumab and Standard Therapy for Metastatic Renal Cell Carcinoma. Completed, enrolled 316 participants across 30 sites in 7 countries.

Detailed Summary

SUNNIFORECAST (Standard of Care vs. Nivolumab + Ipilimumab as First line treatment of renal cell cancer of non-clear cell subtypes) is a Phase II, randomized, open-label investigator initiated trial (IIT) of Nivolumab (BMS-936558) combined with Ipilimumab vs standard of care in subjects with previously untreated and advanced (unresectable or metastatic) non-clear cell renal cell carcinoma (nccRCC).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesBelgium, Czechia, France, Germany, Netherlands, Spain, United Kingdom
Collaborators--

Timeline

Phase 2CompletedFinished
2017201820192020202120222023202420252026
First PostedMar 9, 2017
Enrollment StartNov 1, 2017
Primary CompletionNov 23, 2023
TodayJul 2, 2026
Enrollment to primary: 6.1 yearsPosted 9.3 years ago

Interventions

Ipilimumab plus nivolumabdrug

Ipilimumab every 3 weeks for 4 times Nivolumab every 3 weeks for 4 times followed by maintenance therapy with nivolumab every 2nd or 4th week

Standard Therapydrug

Standard of Care therapy is administered according to the physician´s decision.