At a glance
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Adrenergic Contribution to Glucose Counterregulation in Islet Transplantation
In Brief
A Early Phase 1 clinical trial evaluating Phentolamine, Propranolol, and 1 other intervention for Type1diabetes and 3 related conditions. Completed, enrolled 9 participants across 1 site.
Detailed Summary
To determine the effect of sympathetic neural and hormonal (epinephrine) input on islet cell hormonal responses to insulin-induced hypoglycemia in type 1 diabetic recipients of intrahepatic islet transplantation. We hypothesize that α-adrenergic (neural) blockage will abolish insulin-mediated suppression of C-peptide, attenuating α-cell glucagon secretion during hypoglycemia, and that β-adrenergic (hormonal) blockage will have no effect. Glucose counterregulatory responses will be measured during hyperinsulinemic euglycemic-hypoglycemic clamps on three occasions with randomized, double-blind administration of the α-adrenergic blocker phentolamine, the β-adrenergic blocker propranolol, or placebo. The demonstration of neural rather than hormonal regulation of the transplanted islet cell response to hypoglycemia is critical for understanding the mechanism for protection from hypoglycemia afforded by intrahepatically transplanted.
Study Details
Timeline
Interventions
Physiologic receptor blockade (α1-receptor).
Physiologic receptor blockade (β2-receptor).
100mL bag of Normal Saline Solution (NSS).