CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 134 enrolled
Drug / intervention
Bupivacaine +5 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03084536
NCT03084536Phase 2Completed
CompareCT.gov

PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery

Washington University School of Medicine·interventional·Posted Mar 21, 2017·Updated Dec 24, 2024

In Brief

A Phase 2 clinical trial evaluating Bupivacaine, Gabapentin, and 4 other interventions for Breast Cancer and 2 related conditions. Completed, enrolled 134 participants across 1 site.

Detailed Summary

In this double blinded randomized placebo-controlled trial, 160 subjects scheduled for breast surgery involving the axilla will be administered a multimodal pain regimen including acetaminophen, dexamethasone, celecoxib, and gabapentin. 80 subjects will also receive a Pectoral Nerve blocks I and II (PECS I and II block) preoperatively.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsBreast Cancer, Breast Cancer Female, Cancer of Breast
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2017201820192020202120222023202420252026
First PostedMar 21, 2017
Enrollment StartJun 7, 2017
Primary CompletionFeb 25, 2021
TodayJul 2, 2026
Enrollment to primary: 3.7 yearsPosted 9.3 years ago

Interventions

Bupivacainedrug

-Given after general anesthesia

Gabapentindrug

* As per routine care * Will not be prescribed for any patient with preexisting kidney disease or ≥ 65 years.

Celecoxibdrug

* As per routine care * Will not be prescribed for any patient with preexisting kidney disease or ≥ 65 years. * Naproxen will be substituted for celecoxib in patients with sulfa allergies.

Acetaminophendrug

-As per routine care

Midazolamdrug

-As per routine care

Fentanyldrug

-As per routine care