At a glance
ClinicalIndex Comparison RecordPhase 1Completed· 11 enrolled
Drug / intervention
siRNA-transfected Peripheral Blood Mononuclear Cells (PBMC) APN401 +1 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Safety and Immunologic Activity of Multiple Infusions of APN401
In Brief
A Phase 1 clinical trial evaluating Laboratory Biomarker Analysis and siRNA-transfected Peripheral Blood Mononuclear Cells (PBMC) APN401 for Metastatic Malignant Neoplasm in the Brain and 11 related conditions. Completed, enrolled 11 participants across 1 site.
Detailed Summary
This phase I trial studies the side effects and best dose of APN401 in treating patients with pancreatic cancer, colorectal cancer, or other solid tumors that have spread to other places in the body or have come back. APN401 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMetastatic Malignant Neoplasm in the Brain, Metastatic Solid Neoplasm, Recurrent Colorectal Carcinoma, Recurrent Pancreatic Carcinoma, Recurrent Solid Neoplasm, Stage IV Colorectal Cancer, Stage IV Pancreatic Cancer, Stage IVA Colorectal Cancer, Stage IVA Pancreatic Cancer, Stage IVB Colorectal Cancer, Stage IVB Pancreatic Cancer, Unresectable Solid Neoplasm
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI)
Timeline
Phase 1CompletedFinished
2017201820192020202120222023202420252026
First PostedMar 2017
Enrollment StartApr 2017
Primary CompletionJul 2019
Study CompletionDec 2020
TodayJul 2026
First PostedMar 22, 2017
Enrollment StartApr 28, 2017
Primary CompletionJul 31, 2019
Study CompletionDec 8, 2020
TodayJul 2, 2026
Enrollment to primary: 2.3 yearsPosted 9.3 years ago
Interventions
Laboratory Biomarker Analysisother
Correlative studies
siRNA-transfected Peripheral Blood Mononuclear Cells (PBMC) APN401biological
Given IV