CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 316 enrolled
Drug / intervention
Isoniazid +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03089983
NCT03089983N/ACompleted
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Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings

Yale University·interventional·Posted Mar 24, 2017·Updated Feb 9, 2026

In Brief

A clinical study evaluating Isoniazid and Rifapentine for Opioid Dependence and 4 related conditions. Completed, enrolled 316 participants across 1 site.

Detailed Summary

The purpose of this study is to conduct empiric studies of tuberculosis (TB) among people in prison with and without a history of opioid dependence. A RCT of latent TB infection prevention strategies among HIV+ and HIV- prisoners with high prevalence of hepatitis C (HCV) using standard 40-week daily isoniazid (40H) vs short-course weekly isoniazid + rifapentine (12HR). Investigators will also use this data, and publicly available data to complete agent-based modeling for comparative and cost-effectiveness of various TB screening and treatment strategies among prisoners.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsOpioid Dependence, Addiction, HIV/AIDS, Tuberculosis, Hepatitis
CountriesMalaysia
CollaboratorsUniversity of Malaya, National Institute on Drug Abuse (NIDA)

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedMar 24, 2017
Enrollment StartAug 21, 2017
Primary CompletionApr 4, 2024
TodayJul 2, 2026
Enrollment to primary: 6.6 yearsPosted 9.3 years ago

Interventions

Isoniaziddrug

Participants will be randomized to receive standard INH as TB preventative treatment

Rifapentinedrug

Participants will be randomized to receive short course INH + RIF as TB preventative treatment