At a glance
ClinicalIndex Comparison Record- ✓Diagnosis of generalized aggressive periodontitis per Armitage 1999 or AAP 2015 criteria
- ✓Prior full-mouth ultrasonic debridement completed (first-line periodontal treatment)
- ✓At least one residual probing depth ≥5 mm with bleeding on probe (not in furcation)
- ✓Good general health status
- ✕ASA Class III-V (serious systemic disease: cardiovascular alterations, blood dyscrasias, immunodeficiency)
- ✕Antibiotic or anti-inflammatory use in prior 6 months
- ✕Smoking ≥10 cigarettes per day
- ✕Pregnant or lactating women
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Evaluation of Omega-3 Polyunsaturated Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial
In Brief
A Phase 3 clinical trial evaluating Open flap debridement, Placebo, and 2 other interventions for Residual Disease and Aggressive Periodontitis. Completed, enrolled 34 participants across 1 site.
Detailed Summary
The aim of this randomized controlled clinical trial of superiority will be to evaluate the effect of 3 g of omega-3 polyunsaturated fatty acids and 100 mg of aspirin daily supplementation over a period of 180 days as adjunct to surgical therapy of residual pockets from patients with generalized aggressive periodontitis. Probing depth, clinical attachment level, gingival index and concentration of microorganisms and cytokines at baseline, 3, and 6 months after the procedure will be evaluated.
Study Details
Timeline
Interventions
Open flap debridement will be performed to decontaminate root surface
Placebo pills over a period of 180 days
3 g of omega-3 polyunsaturated fatty acids daily supplementation over a period of 180 days
100 mg of aspirin daily supplementation over a period of 180 days