At a glance
ClinicalIndex Comparison Record- ✓Diagnosis of generalized aggressive periodontitis (GAgP) per AAP 1999 classification
- ✓At least 20 teeth present
- ✓At least 6 sites with probing depth ≥5mm and bleeding on probing, plus ≥2 sites with probing depth ≥7mm (including incisors and first molars plus two other non-contiguous teeth)
- ✓Good general health
- ✕Pregnancy or lactating
- ✕Systemic disease (cardiovascular disorders, diabetes, blood dyscrasias, immunodeficiency, etc) that could alter periodontal disease course
- ✕Antimicrobial use within the previous 6 months
- ✕Current long-term anti-inflammatory drug use
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Evaluation of Omega-3 Polyunsaturated Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial
In Brief
A Phase 3 clinical trial evaluating Omega-3 polyunsaturated fatty acids, Aspirin, and 2 other interventions for Aggressive Periodontitis. Completed, enrolled 38 participants across 1 site.
Detailed Summary
The aim of this randomized controlled clinical trial of superiority will be to evaluate the effect of 3 g of omega-3 polyunsaturated fatty acids and 100 mg of aspirin daily supplementation over a period of 180 days as adjunct to non-surgical therapY of patients with generalized aggressive periodontitis. Probing depth, clinical attachment level, gingival index and concentration of microorganisms and cytokines at baseline, 3, and 6 12 months after the procedure will be evaluated.
Study Details
Timeline
Interventions
3 g of omega-3 polyunsaturated fatty acids daily supplementation over a period of 180 days
100 mg of aspirin daily supplementation over a period of 180 days
Placebo pills over a period of 180 days
Full-mouth ultrasonic debridement will be performed in order to treat diseased sites