CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 86 enrolled
Drug / intervention
Bupivacaine with epinephrine +7 moredrug
Likely dose
Methylprednisolone 40 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03094663
NCT03094663Phase 4Completed
CompareCT.gov

Analgesia After Total Knee Arthroplasty: Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI). A Double-Blinded Randomized Controlled Trial

Hospital for Special Surgery, New York·interventional·Posted Mar 29, 2017·Updated Dec 27, 2024

In Brief

A Phase 4 clinical trial evaluating Bupivacaine with epinephrine, Methylprednisolone, and 6 other interventions for Knee Arthropathy. Completed, enrolled 86 participants across 1 site.

Detailed Summary

A comparison of two pain control methods - the combination of Adductor Canal Block (ACB)/Periarticular Injection (PAI)/Infiltration of the interspace between the popliteal artery and the capsule of the posterior knee (IPACK) versus the Periarticular Injection (PAI) - in patients undergoing total knee arthroplasty. Primary outcome is NRS pain scores with ambulation on postoperative day one (24 hours post-block administration).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsKnee Arthropathy
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
2017201820192020202120222023202420252026
First PostedMar 29, 2017
Enrollment StartFeb 28, 2017
Primary CompletionMay 31, 2018
Study CompletionSep 1, 2018
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 9.3 years ago

Interventions

Bupivacaine with epinephrinedrug

bupivacaine 0.5% with epinephrine 30cc

Methylprednisolonedrug

40 mg/ml, 1 ml

Cefazolindrug

500 mg in 10 ml

8 MHz. Chiba needledevice

22G/ 4 inches

Bupivacaine with Dexamethasonedrug

15 cc of bupivacaine 0.25% with 2 mg of PF Dexamethasone

Bupivacaine 25ccdrug

25 cc 0.25% bupivacaine

Bupivacaine 20ccdrug

20cc 0.25% bupivacaine

Dexamethasonedrug

2 mg IV dexamethasone.