At a glance
ClinicalIndex Comparison Record- ✓Scheduled for gynecological surgery under short general anesthesia (1–3 hours)
- ✓ASA physical status I–II
- ✓Written informed consent obtained
- ✕Coronary heart disease, bronchial asthma, cardiac, lung, hepatic, or renal insufficiency
- ✕Severe hypertension, diabetes, or obesity (BMI > 30)
- ✕Chronic pain history, alcohol or opioid abuse, or pre-existing opioid therapy
- ✕Pregnancy or psychiatric disease
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Effect of Dexmedetomidine Combined With Low-dose Nalmefene on Preventing Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Gynecological Surgery
In Brief
A clinical study evaluating Normal saline, Remifentanil, and 3 other interventions for Pain and Anesthesia. Completed, enrolled 150 participants across 1 site.
Detailed Summary
To explore and compare antihyperalgesic effects of Dexmedetomidine,Nalmefene,and a combination of both received before anesthesia induction. To evaluate and examine the incidence of adverse effects with the purpose of selecting the optimum dose.
Study Details
Timeline
Interventions
Normal saline is intravenously administrated before anesthesia induction
Remifentanil is intravenously administrated
Sufentanil is intravenously administrated
Dexmedetomidine is intravenously administrated before anesthesia induction
Nalmefene is intravenously administrated before anesthesia induction