CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 104 enrolled
Drug / intervention
High dose Aspirin & Vitamin D +5 moredrug
Likely dose
High dose Aspirin & Vitamin D 300mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03103152
NCT03103152Phase 3Completed
CompareCT.gov

PROVENT: A Randomised, Double Blind, Placebo Controlled Feasibility Study to Examine the Clinical Effectiveness of Aspirin and/or Vitamin D3 to Prevent Disease Progression in Men on Active Surveillance for Prostate Cancer

Queen Mary University of London·interventional·Posted Apr 6, 2017·Updated Mar 29, 2023

In Brief

A Phase 3 clinical trial evaluating High dose Aspirin & Vitamin D, High dose Aspirin, Vitamin D placebo, and 4 other interventions for Prostate Cancer. Completed, enrolled 104 participants across 7 sites.

Detailed Summary

To demonstrate the acceptability and feasibility of recruitment to a randomised chemoprevention study of standard (300mg) or low dose (100mg) aspirin vs. placebo and/or Vitamin D3 vs. placebo in patients enrolled on an Active Surveillance programme for prostate cancer.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsProstate Cancer
CountriesUnited Kingdom
CollaboratorsBarts and the London School of Medicine and Dentistry, Cancer Research UK

Timeline

Phase 3CompletedFinished
2017201820192020202120222023202420252026
First PostedApr 6, 2017
Enrollment StartDec 1, 2016
Primary CompletionMar 31, 2020
TodayJul 2, 2026
Enrollment to primary: 3.3 yearsPosted 9.2 years ago

Interventions

High dose Aspirin & Vitamin Ddrug

Aspirin 1 x 300mg tablet daily \& Vitamin D 4,000IU daily. (8 drops).

High dose Aspirin, Vitamin D placebodrug

Aspirin 1 x 300mg tablet daily \& Vitamin D placebo (8 drops).

Low dose Aspirin , Vitamin Ddrug

Aspirin 1 x 100mg tablet daily \& Vitamin D 4,000IU daily. (8 drops).

Low dose Aspirin, Vitamin D placebodrug

Aspirin 1 x 100mg tablet daily \& Vitamin D placebo 8 drops daily.

Aspirin Placebo, Vitamin Ddrug

Aspirin 1 x 300mg placebo tablet daily \& Vitamin D 4,000IU daily. (8 drops).

Aspirin placebo, Vitamin D placebodrug

Aspirin 1 x 100mg placebo tablet daily \& Vitamin D 4,000IU daily. (8 drops).