CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 60 enrolled
Drug / intervention
Minocycline Hydrochloride 100mg Capsule +2 moredrug
Likely dose
Minocycline Hydrochloride 100mg Capsulefrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03106740
NCT03106740Phase 2Completed
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Imaging Glia-mediated NeuroInflammation and Treatment Efficacy (the IGNITE Study)

Marco Loggia·interventional·Posted Apr 10, 2017·Updated Feb 11, 2026

In Brief

A Phase 2 clinical trial evaluating Minocycline Hydrochloride 100mg Capsule, Magnetic Resonance-Positron Emission Tomography Imaging, and 1 other intervention for Low Back Pain and 5 related conditions. Completed, enrolled 60 participants across 1 site.

Detailed Summary

In this research, the study team will use brain imaging to evaluate the presence of neuroinflammation in the brains and spinal cords of patients with low back pain. The efficacy of minocycline use for low back pain treatment will also be evaluated by observing whether short-term minocycline administration will reduce neuroinflammation and low back pain symptoms.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsLow Back Pain, Back Pain With Radiation, Back Pain Without Radiation, Back Pain Lower Back Chronic, Back Ache, Pain, Chronic
CountriesUnited States
CollaboratorsNational Institute of Neurological Disorders and Stroke (NINDS)

Timeline

Phase 2CompletedFinished
201820192020202120222023202420252026
First PostedApr 10, 2017
Enrollment StartOct 10, 2017
Primary CompletionApr 30, 2024
TodayJul 2, 2026
Enrollment to primary: 6.6 yearsPosted 9.2 years ago

Interventions

Minocycline Hydrochloride 100mg Capsuledrug

Minocycline 100mg will be administered by mouth daily for 2 weeks

Magnetic Resonance-Positron Emission Tomography Imagingother

Up to 15 millicuries of \[11C\]PBR28 will be administered to each subject at each imaging visit, for a maximum of 2 imaging visits.

Placebo Capsuleother

1 Placebo Capsule (compounded with lactose powder) will be administered by mouth daily for 2 weeks