At a glance
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Plasma and Urine Metabolomics for Biomarker Discovery in Children With Eosinophilic Esophagitis
In Brief
An observational study evaluating Plasma and urine metabolomics for Eosinophilic Esophagitis. Completed, enrolled 24 participants across 1 site.
Detailed Summary
The investigators are seeking to enroll 8 children ages 2-18 already undergoing upper endoscopy. For the purposes of research, a peripheral blood and clean catch urine specimen will be obtained to measure plasma and urine metabolomics. The data will be used to determine if there are any key differences in the metabolite profile of subjects found to have eosinophilic esophagitis (EoE) versus non-EoE subjects. Once these metabolites are identified, the investigators will seek to enroll many more subjects for a validation phase.
Study Details
Timeline
Interventions
Through the use of high-pressure liquid chromatography and mass spectrometry, quantitative measurements of targeted metabolites associated with amino acids, methylation, acetylation and the tricarboxylic acid (TCA) cycle will be analyzed on the blood and urine specimens.