At a glance
ClinicalIndex Comparison RecordEarly Ph 1Completed· 9 enrolled
Drug / intervention
Metformin Hydrochloride +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Pilot Study of Metformin in Head and Neck Cancer and Its Effect on Proinflammatory Cytokines and Exosomes Implicated in Acute and Chronic Toxicity
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University·interventional·Posted Apr 12, 2017·Updated Apr 30, 2025
In Brief
A Early Phase 1 clinical trial evaluating External Beam Radiation Therapy, Metformin Hydrochloride, and 1 other intervention for Larynx and 3 related conditions. Completed, enrolled 9 participants across 1 site.
Detailed Summary
This pilot clinical trial studies how well metformin hydrochloride works in affecting cytokines and exosomes in patients with head and neck cancer. Metformin hydrochloride may reduce the metabolic activity of cancer cells and of surrounding supportive tissues.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsLarynx, Lip, Oral Cavity, Pharynx
CountriesUnited States
Collaborators--
Timeline
Early Ph 1CompletedFinished
2017201820192020202120222023202420252026
Enrollment StartJan 2017
First PostedApr 2017
Primary CompletionJul 2020
TodayJul 2026
First PostedApr 12, 2017
Enrollment StartJan 5, 2017
Primary CompletionJul 31, 2020
TodayJul 2, 2026
Enrollment to primary: 3.6 yearsPosted 9.2 years ago
Interventions
External Beam Radiation Therapyradiation
Undergo External Beam Radiation Therapy
Metformin Hydrochloridedrug
Given orally
Placeboother
Given orally