At a glance
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Accelerated TMS to a Novel Brain Target in MDD and PTSD
In Brief
A clinical study evaluating Transcranial Magnetic Stimulation (TMS), Task, and 1 other intervention for Post Traumatic Stress Disorder and Major Depressive Disorder. Completed, enrolled 50 participants across 1 site.
Detailed Summary
This is a Clinical Trial designed to evaluate novel transcranial magnetic stimulation (TMS) methods for treating depression/PTSD. TMS is an FDA-approved procedure for treatment-resistant depression. The use of the stimulation in this current study is considered experimental. The purpose of this research study is to compare the effects of TMS at two different brain regions. This information will help the investigators to determine which treatment strategies provide the greatest clinical benefit to patients. Results of the study will provide brain and behavior measures for future work, which may be critical to developing effective disease markers and novel treatments for psychiatric conditions.
Study Details
Timeline
Interventions
Transcranial Magnetic Stimulation (TMS) is a non-invasive form of brain stimulation. TMS can influence activity in various brain regions, and it allows researchers to test or modify brain circuit communication. In this study, we used administered theta burst TMS stimulation.
Subject completes a working memory task (Letter Nback) between the two rounds of theta burst stimulation.
Administration of TMS to individualized targeting from the participant's fMRI scans. Our preliminary data suggest this target region is particularly effective at influencing the sgACC.