At a glance
ClinicalIndex Comparison Record- ✓Body mass index less than 40 kg/m²
- ✓Mini Mental State Examination score of 26 or higher (out of 30)
- ✓Stable body weight for at least 3 months
- ✓Either non-diabetic or have Type 2 Diabetes Mellitus
- ✕Pre-diabetes per American Diabetes Association criteria
- ✕Insulin therapy, significant diabetic complications, or HbA1c >8%
- ✕Impairment in Activities of Daily Living
- ✕More than 2 falls per year
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Identifying Therapeutic Targets of Accelerated Sarcopenia
In Brief
A clinical study evaluating Resistance exercise training, Bed rest, and 1 other intervention for Sarcopenia and 2 related conditions. Completed, enrolled 95 participants across 1 site.
Detailed Summary
The proposed research is designed to identify the mechanisms that can accelerate loss of muscle size, strength and physical function in type 2 diabetes and with hospitalization in older persons. About ⅓ of older Americans have type 2 diabetes, and about ⅓ of the hospitalizations in the USA involve persons older than 65 year of age. The proposed research is relevant to the part of NIH's mission that pertains to development of the fundamental knowledge that will improve health and reduce the burdens of disability, because this work will provide the fundamental evidence to identify new targets for the development of innovative treatments to slow down muscle loss and disability in our aging society.
Study Details
Timeline
Interventions
Supervised resistance exercise training, 3 times a week for 3 months
Bed rest for 5 days, followed by standard rehabilitation for 2 days
Intensive weight bearing PT, daily, during bed rest