CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 182 enrolled
Drug / intervention
Simplify Discdevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03123549
NCT03123549N/ACompleted
CompareCT.gov

Clinical Study Protocol for the Investigation Of The Two Level Simplify® Cervical Artificial Disc

NuVasive·interventional·Posted Apr 21, 2017·Updated Jan 8, 2026

In Brief

A clinical study evaluating Simplify Disc for Cervical Degenerative Disc Disorder. Completed, enrolled 182 participants across 18 sites.

Detailed Summary

This study is intended to demonstrate that the Simplify® Cervical Artificial Disc (Simplify® Disc) is at least as safe and effective as conventional anterior cervical discectomy and fusion (ACDF) when used to treat two contiguous discs from C3 to C7 following discectomy at two contiguous levels for intractable radiculopathy (arm pain and/or a neurological deficit) with neck pain or myelopathy due to abnormalities localized to the levels of the two contiguous disc spaces in subjects who are unresponsive to conservative management.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCervical Degenerative Disc Disorder
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedApr 21, 2017
Enrollment StartApr 1, 2017
Primary CompletionNov 12, 2020
Study CompletionMar 24, 2022
TodayJul 2, 2026
Enrollment to primary: 3.6 yearsPosted 9.2 years ago

Interventions

Simplify Discdevice

Simplify Disc at two levels of the cervical spine