CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 105 enrolled
Drug / intervention
Sertraline +2 moredrug
Likely dose
Sertraline 50 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03126188
NCT03126188N/ACompleted
CompareCT.gov

Study of the Effect of Antidepressant Drugs on Neurotrophic Factors in Patients With Depression

All India Institute of Medical Sciences, Bhubaneswar·observational·Posted Apr 24, 2017·Updated Jul 11, 2018

In Brief

An observational study evaluating Sertraline, Dosulepin, and 1 other intervention for Depressive Episode. Completed, enrolled 105 participants across 1 site.

Detailed Summary

The aim of the present study will be to observe the changes in the NTs like Nerve growth factor, Neurotrophin-3, and Neurotrophin-4 in patients with depression and study the effect of various antidepressants like Sertraline (SSRI), Dosulepin (TCA), and Venlafaxine (SNRI) on their levels.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsDepressive Episode
CountriesIndia
Collaborators--

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedApr 24, 2017
Enrollment StartApr 5, 2017
Primary CompletionDec 31, 2017
Study CompletionFeb 28, 2018
TodayJul 2, 2026
Enrollment to primary: 9 monthsPosted 9.2 years ago

Interventions

Sertralinedrug

Tab. Sertraline 50 mg/day, which will be optimized to 75mg/day after 2 weeks if required, and maintained on the same dose for a minimum period of 6 weeks.

Dosulepindrug

Tab. Dosulepin 25mg/day, which will be gradually hiked up to 75mg/day over 2 weeks,and the patients will be continued on the same dose for a minimum period of 6 weeks.

Venlafaxinedrug

Tab. Venlafaxine 75mg/day, which will be hiked to 112.5 mg/day after 2 weeks, and the patients will be continued on the same dose for a minimum period of 6 weeks.