At a glance
ClinicalIndex Comparison RecordPhase 3Completed· 66 enrolled
Drug / intervention
Topical epinephrine +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Prophylactic Topical Epinephrine to Reduce Transbronchial Lung Biopsy-related Hemorrhage in Lung Transplant Recipients: a Prospective Double-blind Placebo-controlled Trial (PROPHylactic Epinephrine in Transbronchial Biopsy [PROPHET] Trial)
In Brief
A Phase 3 clinical trial evaluating Topical epinephrine and Placebos for Lung Transplant; Complications, Mechanical and 3 related conditions. Completed, enrolled 66 participants across 2 sites.
Detailed Summary
Bleeding poses potential for significant complication after transbronchial lung biopsies. The investigators hypothesize that prophylactic intrabronchial instillation of topical epinephrine will reduce the likelihood of bleeding. The investigators plan a double-blind, placebo controlled trial to evaluate this hypothesis.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsLung Transplant; Complications, Mechanical, Lung Transplant; Complications, Bleeding, Hemoptysis
CountriesUnited States
Collaborators--
Timeline
Phase 3CompletedFinished
201820192020202120222023202420252026
First PostedApr 2017
Enrollment StartJul 2017
Primary CompletionJul 2021
TodayJul 2026
First PostedApr 25, 2017
Enrollment StartJul 1, 2017
Primary CompletionJul 2, 2021
TodayJul 2, 2026
Enrollment to primary: 4.0 yearsPosted 9.2 years ago
Interventions
Topical epinephrinedrug
Prophylactic topical epinephrine
Placebosdrug
Topical placebo (normal saline)