At a glance
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A Pragmatic Multi-center Trial of Goal-directed Fluid Management Based on Pulse Pressure Variation Monitoring During High-risk Surgery
In Brief
A clinical study evaluating Pulse pressure variation monitoring for Goal-directed Fluid Therapy and 4 related conditions. Completed, enrolled 256 participants.
Detailed Summary
Background: Intraoperative fluid therapy guided by mechanical ventilation-induced pulse-pressure variation (PPV) may improve outcomes after major surgery. It was tested this hypothesis in a multi-center study. Methods: The patients were included in two periods: a first control period (control group; n=147) in which intraoperative fluids were given according to clinical judgment. After a training period, intraoperative fluid management was titrated to maintain PPV\< 10% in 109 surgical patients (PPV group). It was performed 1:1 propensity score matching to ensure the groups were comparable with regard to age, weight, duration of surgery, and type of operation. The primary endpoint was postoperative hospital length of stay.
Study Details
Timeline
Interventions
fluids boluses of colloids were given to maintain continuously measured PPV at 10% or less