At a glance
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Timing of Vaccination With the Non-live DTaP-IPV-Hib Vaccine and Development of Atopic Dermatitis Before 1 Year of Age - a Danish Register Based Cohort Study
In Brief
An observational study evaluating RQ1a: Delayed vs. timely vaccination with the 1st dose of DTaP-IPV-Hib, RQ1b: Delayed vs. timely vaccination with the 2nd dose of DTaP-IPV-Hib, and 1 other intervention for Atopic Dermatitis. Completed, enrolled 1,027,559 participants.
Detailed Summary
It has been found that the non-live vaccine against Diphtheria, Tetanus, and Pertussis (DTP) in addition to its disease specific effects may have so called "non-specific effects" with the potential to affect sensitivity towards vaccine unrelated pathogens, resulting in excess mortality(Aaby, Kollmann, \& Benn, 2014). A recent study from Australia found that delayed vaccination with the first dose of Diphtheria, Tetanus, and acellular Pertussis(DTaP)-containing vaccine is associated with reduced risk of atopic dermatitis (aOR: 0.57; 95% CI: 0.34-0.97, P = 0.04) and reduced use of medication against atopic dermatitis (aOR: 0.45; 95% CI: 0.24-0.83, P = 0.01)(Kiraly et al., 2016). This register based observational study aims to extend the existing knowledge on non-specific effects of non-live vaccines by testing the above finding, that delayed vaccination with Diphtheria, Tetanus, acellular Pertussis - Inactivated Polio vaccine - Haemophilus influenzae type b (DTaP-IPV-Hib) is associated with lower risk of developing atopic dermatitis before 1 year of age in the Danish birth cohorts from 1997-2012.
Study Details
Timeline
Interventions
Children will be categorized as "timely vaccinated" if they receive the 1st dose within the month of scheduled vaccination: * "timely vaccinated": received 1st dose of DTaP-IPV-Hib before 4 months of age * "delayed vaccinated": did not receive the first dose of DTaP-IPV-Hib before 4 months of age.
Children will be categorized as "timely vaccinated" if they receive the 2nd dose within the month of scheduled vaccination: * "timely vaccinated": received 2nd dose of DTaP-IPV-Hib before 6 months of age * "delayed vaccinated": did not receive the 2nd dose of DTaP-IPV-Hib before 6 months of age.
• Vaccination status will be assessed as a time dependent exposure, whereby children will be categorized as "unvaccinated" until date of vaccination where they will shift exposure group to "vaccinated".