CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 200 enrolled
Drug / intervention
FluMist trivalent (2015-2016) +2 morebiological
Likely dose
FluMist trivalent (2015-2016) 0.2 mLfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03143101
NCT03143101Phase 4Completed

A Phase 4 Double-blind Study to Evaluate the Shedding and Immunogenicity of Trivalent and Quadrivalent Formulations of FluMist in Children 24 to < 48 Months of Age

MedImmune LLC·interventional·Posted May 8, 2017·Updated Dec 11, 2018

In Brief

A Phase 4 clinical trial evaluating FluMist trivalent (2015-2016), FluMist Quadrivalent (2015-2016), and 1 other intervention for Influenza and Healthy. Completed, enrolled 200 participants across 12 sites.

Detailed Summary

This study is being conducted to compare the immunogenicity, safety, and viral shedding of a new A/H1N1 strain that will be incorporated into the FluMist quadrivalent formulation for the 2017-2018 influenza season with the previous A/H1N1 strain that was included in the vaccine in the 2015-2016 influenza season.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsInfluenza, Healthy
CountriesUnited States
CollaboratorsAstraZeneca

Timeline

Phase 4CompletedFinished
201820192020202120222023202420252026
First PostedMay 8, 2017
Enrollment StartMay 8, 2017
Primary CompletionSep 29, 2017
TodayJul 2, 2026
Enrollment to primary: 5 monthsPosted 9.2 years ago

Interventions

FluMist trivalent (2015-2016)biological

0.2 mL (total dose in both nostrils) on Days 1 and 28. Each 0.2 mL dose will contain 10\^7±0.5 FFU of each vaccine strain.

FluMist Quadrivalent (2015-2016)biological

0.2 mL (total dose in both nostrils) on Days 1 and 28. Each 0.2 mL dose will contain 10\^7±0.5 FFU of each vaccine strain.

FluMist Quadrivalent (2017-2018)biological

0.2 mL (total dose in both nostrils) on Days 1 and 28. Each 0.2 mL dose will contain 10\^7±0.5 FFU of each vaccine strain.