CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 60 enrolled
Drug / intervention
Maintainance of anesthesia with Intravenous Propofol infusion +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

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Search/NCT03145714
NCT03145714N/ACompleted
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To Study the Effect of Sevoflurane and Propofol Versus Sevoflurane and Dexmedetomidine on Postoperative Cognitive Dysfunction

Rajiv Gandhi Cancer Institute & Research Center, India·interventional·Posted May 9, 2017·Updated Feb 4, 2019

In Brief

A clinical study evaluating Maintainance of anesthesia with Intravenous Propofol infusion and Maintainance of anesthesia with Intravenous Dexmedetomidine for Postoperative Cognitive Dysfunction. Completed, enrolled 60 participants across 2 sites.

Detailed Summary

Postoperative Cognitive Dysfunction (POCD), is a subtle decline in cognitive function characterized by impairment of memory and reduced ability to concentrate in elderly patients exposed to general anaesthesia. This prospective study aims to compare incidence and severity of POCD in two groups of patients. Group P receiving Intravenous Propofol and Inhalational anesthetic Sevoflurane. Group D receiving Intravenous Dexmedetomidine and Inhalational anesthetic Sevoflurane, Neuropsychological Test will be performed 24 hours before surgery and on postoperative day 3 and day 7.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPostoperative Cognitive Dysfunction
CountriesIndia
Collaborators--

Timeline

N/ACompletedFinished
201820192020202120222023202420252026
First PostedMay 9, 2017
Enrollment StartJun 1, 2017
Primary CompletionFeb 10, 2018
Study CompletionMar 28, 2018
TodayJul 2, 2026
Enrollment to primary: 8 monthsPosted 9.1 years ago

Interventions

Maintainance of anesthesia with Intravenous Propofol infusiondrug

The dosage of Intravenous Propofol will be titrated to maintain BIS Values between 40 -60.

Maintainance of anesthesia with Intravenous Dexmedetomidinedrug

The dosage of Intravenous Dexmedetomidine will be titrated to maintain BIS Values between 40 -60.