At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Effect of Acute Fructose Load in Patients With Chronic Kidney Disease and Patients With Type 2 Diabetes Compared to Healthy Subjects
In Brief
A clinical study evaluating Blueberry drink, Blueberry and pizza, and 4 other interventions for Chronic Kidney Diseases and Diabetes Mellitus, Type 2. Completed, enrolled 20 participants across 1 site.
Detailed Summary
The metabolism of the monosaccharide fructose is less controlled than the metabolism of glucose, which will result in the metabolic product uric acid. Elevated serum uric acid levels are associated with increased risk, or worsening, of chronic kidney disease. The mechanisms by which uric acid have detrimental effects are not well defined, but may include an increase in reactive oxygen species and subsequent inflammatory activity. The aim of this study is to investigate the effects of uric acid, markers of oxidative stress and markers of inflammation following a low fructose load reflecting normal conditions. This is an interventional study. On six different occasions patients with chronic kidney disease, patients with type 2 diabetes and healthy controls will receive Blueberry drink, Coca-Cola or pure Fructose drink with similar amount of carbohydrates (140 kcal) with and without a high fat meal represented by a pizza (425 kcal).Serum samples and urinary samples will be collected.
Study Details
Timeline
Interventions
Participant receive blueberry drink
Participant receive blueberry drink and a slice of pizza
Participant receive a soft beverage drink
Participant receive a soft beverage drink and a slice of pizza
Participant receive a drink containing fructose
Participant receive a fructose drink and a slice of pizza