CI

At a glance

ClinicalIndex Comparison Record
Phase 3Active· 881 enrolled
Drug / intervention
Entonox +5 moredrug
Likely dose
Meperidine 75mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03167905
NCT03167905Phase 3Active
CompareCT.gov

Comparison of the Role of Epidural Analgesia Versus Non-epidural Analgesia in Postnatal Depression and Persistent Pain Development: a Randomized Controlled Trial

KK Women's and Children's Hospital·interventional·Posted May 30, 2017·Updated Apr 18, 2025

In Brief

A Phase 3 clinical trial evaluating Epidural delivery system, Entonox, and 4 other interventions for Depression, Postpartum and 2 related conditions. Active but no longer recruiting, targeting 881 participants across 1 site.

Detailed Summary

Postnatal depression affects about 10-15% of women after childbirth. Approximately 3-5% of women experience a moderate-to-severe depression that requires medical attention. This study aims to investigate the implication of pain relief choice in reducing the postnatal depression of women who deliver their babies.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression, Postpartum, Analgesia, Obstetrical, Anesthesia, Obstetrical
CountriesSingapore
Collaborators--

Timeline

Phase 3Active
2018201920202021202220232024202520262027
First PostedMay 30, 2017
Enrollment StartJun 15, 2017
Primary CompletionJul 19, 2021
Study CompletionDec 31, 2026
TodayJul 2, 2026
Enrollment to primary: 4.1 yearsPosted 9.1 years ago

Interventions

Epidural delivery systemdevice

Epidural delivery system for maintenance of labour epidural analgesia using 0.1% ropivacaine (amide local anaesthetic) with 2mcg/ml fentanyl (opioid) as maintenance solution.

Entonoxdrug

Entonox will be given upon request in non-epidural group.

Meperidinedrug

Intramuscular pethidine (75mg/1.5ml) will be given upon request in non-epidural group.

Ultivadrug

Intravenous patient controlled remifentanil (20-40mcg/ml) is only given when the patient rejects or cannot receive pethidine and entonox in non-epidural group..

Fentanyldrug

Epidural delivery system for maintenance of labour epidural analgesia using 0.1% ropivacaine (amide local anaesthetic) with 2mcg/ml fentanyl (opioid) as maintenance solution.

Ropivacainedrug

Epidural delivery system for maintenance of labour epidural analgesia using 0.1% ropivacaine (amide local anaesthetic) with 2mcg/ml fentanyl (opioid) as maintenance solution.