CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 34 enrolled
Drug / intervention
Dapagliflozin 10mg then Placebo Oral Tablet +1 moredrug
Likely dose
Dapagliflozin 10mg then Placebo Oral Tabletfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03168295
NCT03168295Phase 4Completed
CompareCT.gov

SGLT2 INHIBITION AND STIMULATIION OF ENDOGENOUS GLUCOSE PRODUCTION Significance - PROTOCOL 3: Role of the Renal Nerves in the Increase in EGP in Response to Glucosuria

The University of Texas Health Science Center at San Antonio·interventional·Posted May 30, 2017·Updated Sep 17, 2020

In Brief

A Phase 4 clinical trial evaluating Dapagliflozin 10mg then Placebo Oral Tablet and Placebo Oral Tablet then Dapagliflozin 10mg for Diabetes Mellitus, Type 2. Completed, enrolled 34 participants across 1 site.

Detailed Summary

Purpose/Objectives: Examining the effect of SGLT2 inhibition on EGP and plasma glucose concentration in diabetic and non-diabetic subjects after kidney transplantation (i.e. renal denervation) or in subjects after renal sympathectomy (63) can add insight about the possible role of a neural arc which mediates the changes in plasma glucagon and/or insulin concentration in response to glucosuria.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDiabetes Mellitus, Type 2
CountriesUnited States
CollaboratorsNational Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Timeline

Phase 4CompletedFinished
2017201820192020202120222023202420252026
First PostedMay 30, 2017
Enrollment StartOct 1, 2016
Primary CompletionOct 1, 2018
Study CompletionMay 15, 2019
TodayJul 2, 2026
Enrollment to primary: 2 yearsPosted 9.1 years ago

Interventions

Dapagliflozin 10mg then Placebo Oral Tabletdrug

SGLT2 inhibitor - Dapagliflozin then Placebo

Placebo Oral Tablet then Dapagliflozin 10mgdrug

Placebo then SGLT2 inhibitor - Dapagliflozin