At a glance

ClinicalIndex Comparison Record

N/ACompleted· 150 enrolled

Drug / intervention

Mid trimesteric fetal ultrasonographyradiation

Likely dose

Not stated in record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03169907

NCT03169907N/ACompleted

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Cardiac Functions as a New Method for Evaluation of Fetal Anemia Pre and Post Intrauterine Fetal Blood Transfusion

National Research Centre, Egypt·interventional·Posted May 30, 2017·Updated Apr 9, 2021

In Brief

A clinical study evaluating Mid trimesteric fetal ultrasonography for Fetal Anemia as Antepartum Condition (Diagnosis) and Rh Incompatible Blood Transfusion Nos. Completed, enrolled 150 participants across 1 site.

Detailed Summary

INTRODUCTION Circulatory changes associated with fetal anemia have an important role in maintaining sufficient tissue oxygenation. With fetal anemia, hyperdynamic circulation and increased cardiac output occurred. In current practice, using Doppler in assessment of the peak systolic velocity (PSV) of the middle cerebral artery (MCA) is the main parameter in screening of fetal anemia. Myocardial performance index (MPI) is a noninvasive technique that evaluates systolic and diastolic cardiac function by pulsed Doppler. Patients and Methods: This prospective study will be carried out on Women with singleton pregnancies with Rh isoimmunization who are scheduled to have intrauterine blood transfusion. Selected patients will be monitored weekly from 18 weeks gestational age till 28 weeks of gestational age. Venous and arterial Doppler indices: 1. Middle cerebral artery (MCA) peak systolic velocity (PSV) 2. Umbilical Artery Pulsitility Index (PI) and Resistant Index (RI) 3. Ductus venosus (DV) Doppler Cardiac functions: 1. Global cardiac function evaluated by Modified Myocardial Performance Index (Mod-MPI) 2. Diastolic cardiac function evaluated by relationship between the maximal velocities of the E and A waveforms of ventricular filling (E/A ratio)

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsFetal Anemia as Antepartum Condition (Diagnosis), Rh Incompatible Blood Transfusion Nos

CountriesEgypt

CollaboratorsCairo University

Timeline

N/ACompletedFinished

2017201820192020202120222023202420252026

Enrollment StartApr 2017

First PostedMay 2017

Primary CompletionApr 2018

Study CompletionApr 2019

TodayJul 2026

First PostedMay 30, 2017

Enrollment StartApr 1, 2017

Primary CompletionApr 1, 2018

Study CompletionApr 1, 2019

TodayJul 2, 2026

Enrollment to primary: 1 yearPosted 9.1 years ago

Interventions

Mid trimesteric fetal ultrasonographyradiation

Venous and arterial Doppler indices: 1. Middle cerebral artery (MCA) peak systolic velocity (PSV): 2. Umbilical Artery Pulsitility Index (PI) and Resistant Index (RI): 3. Ductus venosus (DV) Doppler: Cardiac functions: 1. Global cardiac function evaluated by Modified Myocardial Performance Index (Mod-MPI): 2. Systolic cardiac function using the four-dimensional (4D) spatiotemporal imaging correlation (STIC) ultrasound technique: 3. Diastolic cardiac function evaluated by relationship between the maximal velocities of the E and A waveforms of ventricular filling (E/A ratio)