At a glance
ClinicalIndex Comparison Record- ✓Critically ill adult trauma victims (blunt or penetrating)
- ✓Other critically ill surgical patients
- ✓Enteral nutrition required within first 96 hours after injury
- ✓Expected to require nutritional support for at least 1 week
- ✕Significant chronic organ failure
- ✕Severe pre-existing malnutrition prior to ICU admission
- ✕Not expected to survive from traumatic injuries
- ✕Intestinal discontinuity
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Protein-enhanced Enteral Nutrition and Metabolomics in Critically Ill Trauma and Surgical Patients
In Brief
A Phase 3 clinical trial evaluating Protein supplementation and Standard enteral nutrition for Nutrition Disorder and 2 related conditions. Completed, enrolled 500 participants across 1 site.
Detailed Summary
The aim of this study is too determine the effect of enteral protein supplementation on biochemical measures of inflammation and protein metabolism in critically ill surgical patients. The investigators will also collect data on important clinical outcomes, including infectious complications, duration of mechanical ventilation and other measures of recovery from critical illness. Hypothesis: That early supplemental protein will increase serum concentrations of transthyretin at three weeks after the onset of illness or injury. Secondarily, the investigators will test whether supplementation, reduces infectious complications and increases ventilator-free days.
Study Details
Timeline
Interventions
enteral protein supplementation
Standard enteral nutrition.